Saturday, April 13, 2024
Female alopeciaAutoimmune Diseases That Cause Alopecia

Autoimmune Diseases That Cause Alopecia

The human body is a marvel of complexity, where every system operates in a delicate balance to maintain overall health and vitality. However, this intricate harmony can be disrupted when the immune system, the body’s natural defense mechanism, turns against itself. This phenomenon, known as autoimmunity, lies at the heart of a wide array of debilitating conditions, collectively referred to as autoimmune diseases. 

Among the diverse range of autoimmune disorders, some strikingly affect the integumentary system, which includes the skin and its appendages. One such intriguing and often emotionally challenging manifestation of autoimmune diseases is alopecia, a condition characterized by hair loss. While hair loss can be attributed to various factors, autoimmune-related alopecia is particularly perplexing, as it involves the immune system mistakenly targeting hair follicles. 

In this exploration, we will delve into the intriguing interplay between autoimmune diseases and alopecia, shedding light on the mechanisms behind these conditions and potential treatments.

You may be interested: Tests To Diagnose Alopecia

Autoimmune Diseases That Can Cause Hair Loss 

Autoimmune Diseases

Here’s an information to potentially help you identify the source of your thinning locks: 

Thyroid Troubles 

Autoimmune Diseases

Your thyroid gland, a small but mighty part of your body, can sometimes cause big problems when it goes awry. These issues stem from two main conditions: hypothyroidism, where your thyroid doesn’t produce enough hormones, and hyperthyroidism, where it goes into overdrive. Both can lead to hair troubles, among other things. 

When your thyroid misbehaves, it can manifest in various ways. For hypothyroidism, think fatigue, weight gain, dry skin, and muscle aches. On the flip side, hyperthyroidism (also known as Graves’ Disease) might bring weight loss, anxiety, tremors, and a racing heartbeat. 

These conditions mess with essential hormones called T3 and T4, which can, unfortunately, affect your locks. Hair can start falling out on your scalp, body, eyelashes, and eyebrows. Sometimes it falls out in clumps, and sometimes it’s a more even loss. You might also notice changes in your hair’s texture, like it feeling finer or coarser than usual. Dry, itchy scalp and dandruff can also tag along. The best move? Team up with your doctor to tackle your thyroid troubles and the hair loss they bring. 


Meet alopecia areata, a tricky autoimmune skin disorder that can swipe your hair from your scalp, face, and body. Surprisingly, over 6 million folks across the nation deal with this sneaky bandit, according to the National Alopecia Areata Foundation (NAAF). 

This condition can cause hair loss in various ways – it might vanish from your entire scalp, create patches, or leave you with partial hair loss. The good news? Even when it seems like your hair is making a disappearing act, the hair follicles are still alive, meaning your hair can grow back. Some people with alopecia report feeling itching, tingling, or burning on their skin just before they lose their hair. Medical treatments are available, but often, the hair in the affected areas stages a comeback on its own. 


Arthritis might not strike you as an immune system adversary, but the Center for Disease Control (CDC) sees rheumatoid arthritis (RA) as both an autoimmune and inflammatory disease. It targets your joints and can even lead to hair loss. Oddly enough, it’s not RA itself that’s directly causing the hair thinning, but rather the medications used to manage RA and the stress that comes with flare-ups. 

Some RA sufferers also experience scalp inflammation, a known hair loss trigger, along with skin sensations like itching and burning. RA isn’t a DIY battle; it’s one for the pros. Seek guidance from a medical professional if you suspect it’s causing your hair woes. 

Telogen Effluvium 

Ever notice your hair falling out in clumps after a stressful event? That’s telogen effluvium, and it might have a surprising link to autoimmune issues. Research in the Skin Appendage Disorders journal suggests that Hashimoto’s disease, a thyroid condition, could be an instigator. This troublemaker can cause hair loss, slow hair growth, and overall thinning. 

Hashimoto’s comes with more than just hair problems; it brings dry skin, stiff joints, brittle nails, and a swollen thyroid to the party. Don’t hesitate to call your doctor if you’re worried about Hashimoto’s role in your hair’s disappearing act. 


Lupus, a chronic troublemaker, usually shows up with inflammation and pain, especially on your face and scalp. It can also target your hair. Hair loss becomes a reality for some, and those luscious locks can turn brittle. 

Clinical, Cosmetic, and Investigational Dermatology journal explains that hair in lupus sufferers can become fragile, appearing dry and coarse near the hairline. If you’re dealing with lupus-related hair issues, your first step is to chat with your doctor about potential solutions. 

Hair Loss Solutions For Autoimmune Disorders 

When autoimmune diseases trigger hair loss, the focus isn’t just on regrowing hair, but on addressing the root cause. Think of it like fixing a dripping faucet; you can keep cleaning up the mess, but unless you fix the leak, it’ll persist. The method to repair this leaky faucet depends on its specific cause. 

FDA-Approved Medication 

Baricitinib, marketed as Olumiant, stands as the sole FDA-approved drug for treating alopecia areata and alopecia totalis in such cases. It operates as an immunosuppressive medication, albeit with an increased susceptibility to infections. Hence, healthcare providers usually explore alternative “off-label” treatments initially, which pose fewer potential side effects. 

Exploring Off-Label Medications 

While off-label medications lack FDA endorsement, studies affirm their reasonable safety and effectiveness. For instance, steroids (available topically, orally, or via injections) and prescription creams like minoxidil (commonly known as Rogaine) or anthralin can offer relief. Additionally, ongoing research may unveil more treatment possibilities in the future. 

Addressing Systemic Autoimmune Conditions 

When tackling hair loss stemming from systemic autoimmune ailments affecting multiple body parts, the primary strategy centers on treating the underlying condition. In simple terms, if lupus causes your hair loss, addressing lupus can alleviate this symptom. The effectiveness of treatment may vary based on the specific autoimmune condition, so consult your healthcare provider to better understand what outcomes to anticipate from the chosen treatment approach. 


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